Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.77 |
| ▸ | EGLN2 | Q96KS0 | 14/20 | 0.63 |
| ▸ | THRA | P10827 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.57 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | ASPH | Q12797 | 1/20 | 0.56 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757879 | 0.96 | EGLN1 (0.72) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523054 | 0.96 | EGLN1 (0.70) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL523169 | 0.96 | EGLN1 (0.70) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL523170 | 0.96 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL30274462 | 0.96 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL522721 | 0.96 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL4758056 | 0.94 | EGLN1 (0.68) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL5072579 | 0.93 | EGLN1 (0.67) | EGLN1EGLN2THRATHRB | |
| SCHEMBL5027659 | 0.91 | EGLN1 (0.72) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL5073118 | 0.91 | EGLN1 (0.72) | EGLN1EGLN2THRATHRBBBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |