Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 10/20 | 0.62 |
| ▸ | JAK3 | P52333 | 8/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | JAK1 | P23458 | 2/20 | 0.58 |
| ▸ | TYK2 | P29597 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486643 | 0.92 | STAT6 (0.73) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2695039 | 0.92 | JAK3 (0.57) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12301690 | 0.92 | STAT6 (0.60) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12301574 | 0.90 | JAK3 (0.73) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12206772 | 0.90 | JAK3 (0.73) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL4403266 | 0.90 | SYK (0.59) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2694523 | 0.87 | JAK3 (0.54) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12322720 | 0.86 | STAT6 (0.60) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2695069 | 0.85 | STAT6 (0.64) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12301688 | 0.85 | STAT6 (0.61) | STAT6JAK3IRAK4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975027-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
| US-9102625-B2 | Nicotinamides as JAK kinase modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-9102625-B2 | Nicotinamides as JAK kinase modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | STAT6 79/4885JAK3 4/4885IRAK4 37/4885 |
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | STAT6 79/4885JAK3 4/4885IRAK4 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.