Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Venlafaxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 10/20 | 0.88 |
| ▸ | SLC6A4 known ✓ | P31645 | 10/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.88 |
| ▸ | LMNA | P02545 | 1/20 | 0.88 |
| ▸ | CNR1 | P21554 | 1/20 | 0.88 |
| ▸ | HTR2A | P28223 | 1/20 | 0.88 |
| ▸ | HRH1 | P35367 | 1/20 | 0.88 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.88 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Venlafaxine SCHEMBL18317298 | 0.99 | SLC6A2 (0.88) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Venlafaxine SCHEMBL35154 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| (S)-Venlafaxine SCHEMBL3644633 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Venlafaxine SCHEMBL1560692 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL10614031 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Venlafaxine SCHEMBL27838459 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| SCHEMBL10616028 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Venlafaxine SCHEMBL60857 | 0.94 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| Venlafaxine SCHEMBL3705529 | 0.92 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3LMNACNR1 | |
| (S)-Venlafaxine SCHEMBL4512264 | 0.92 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2085402-A1 | Phosphates of secondary alcohols | Vital Health Sciences Pty Ltd. (AU) | 2009-08-05 | — | — | EP | disclosed |
| EP-1615936-A4 | PHOSPHATES OF SECONDARY ALCOHOLS | VITAL HEALTH SCIENCES PTY LTD (AU) | 2008-04-30 | — | — | EP | disclosed |
| US-20060281715-A1 | Phosphates of secondary alcohols | VITAL HEALTH SCIENCES PTY. LTD (AU) | 2006-12-14 | — | — | US | disclosed |
| EP-1615936-A1 | PHOSPHATES OF SECONDARY ALCOHOLS | Vital Health Sciences Pty Ltd. (AU) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092186-A1 | PHOSPHATES OF SECONDARY ALCOHOLS | VITAL HEALTH SCIENCES PTY LTD (AU) | 2004-10-28 | — | — | WO | disclosed |