SCHEMBL4411966

SCHEMBL4411966

CCc1occc1Nc1c(F)cc(I)cc1F

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 7/20 0.33
MAP2K2 P36507 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14066486 0.67
SCHEMBL9628732 0.56
SCHEMBL257113 0.56
SCHEMBL21931627 0.56 MAP2K1 (0.41) MAP2K1MAP2K2
SCHEMBL257063 0.56 AKR1B1 (0.35) MAP2K1MAP2K2
SCHEMBL4412928 0.55
SCHEMBL5164012 0.55
SCHEMBL4722781 0.55
Hydrochloric Acid SCHEMBL28391176 0.55 MAP2K2 (0.30) MAP2K1MAP2K2
SCHEMBL18074305 0.54 MAP2K1 (0.38) MAP2K1MAP2K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069354-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE Genentech, Inc. (US) 2009-06-17 EP disclosed
WO-2008024725-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2008-02-28 WO disclosed