Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.49 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CD74 | P04233 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604404 | 0.92 | HRH3 (0.53) | HRH3HRH4MRGPRX4 | |
| SCHEMBL603237 | 0.92 | HRH3 (0.53) | HRH3HRH4 | |
| SCHEMBL605017 | 0.90 | HRH3 (0.55) | HRH3HRH4 | |
| SCHEMBL20472944 | 0.87 | HRH3 (0.52) | HRH3HRH4ADCY10LOXL2MPO | |
| SCHEMBL605322 | 0.85 | HRH3 (0.57) | HRH3HRH4 | |
| SCHEMBL603974 | 0.85 | HRH3 (0.48) | HRH3HRH4TLR8TLR7MRGPRX4 | |
| SCHEMBL605526 | 0.82 | HRH3 (0.53) | HRH3HRH4 | |
| SCHEMBL605523 | 0.82 | HRH3 (0.53) | HRH3HRH4 | |
| SCHEMBL16822318 | 0.82 | HRH3 (0.53) | HRH3HRH4ADCY10TLR8TLR7 | |
| SCHEMBL603256 | 0.80 | HRH3 (0.60) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-9526725-B2 | Selective histamine H4 receptor antagonists for the treatment of vestibular disorders | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2016-12-27 | — | — | US | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| WO-2009077608-A1 | 2 -AMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS | PALAU PHARMA, S. A. (ES) | 2009-06-25 | — | — | WO | disclosed |