Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 1.00 |
| ▸ | DUSP3 | P51452 | 9/20 | 1.00 |
| ▸ | PTPRC | P08575 | 5/20 | 1.00 |
| ▸ | DUSP1 | P28562 | 5/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 5/20 | 1.00 |
| ▸ | CDC25A | P30304 | 4/20 | 1.00 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PLEC | Q15149 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.56 |
| ▸ | DUSP4 | Q13115 | 1/20 | 0.56 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | GALK1 | P51570 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412367 | 1.00 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL4410666 | 0.91 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL4410661 | 0.91 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL8931565 | 0.90 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL1904707 | 0.90 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL1904709 | 0.90 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL1904704 | 0.90 | PTPN1 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL7859598 | 0.87 | DUSP3 (0.90) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL1903068 | 0.87 | DUSP3 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 | |
| SCHEMBL1903069 | 0.87 | DUSP3 (1.00) | PTPN1DUSP3PTPRCDUSP1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188080-B2 | VHR protein tyrosine phosphatase inhibitors, compositions and methods of use | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090105254-A1 | VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105254-A1 | VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE | PTPRR, PTPRS, PTPRCAP | PTPN1 15/4885DUSP3 56/4885PTPRC 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.