Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 4/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200991 | 0.89 | PI4KA (0.59) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL2196289 | 0.85 | CYP1A2 (0.56) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4263700 | 0.79 | SMN1; SMN2 (0.50) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1789417 | 0.77 | MERTK (0.47) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30984000 | 0.76 | CYP2C19 (0.61) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4572213 | 0.75 | CYP2C19 (0.74) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL31569297 | 0.75 | CYP2C19 (0.74) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL31269439 | 0.75 | CYP2C19 (0.60) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1789418 | 0.74 | CYP2C19 (0.41) | CYP2C19PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1324553 | 0.74 | CYP2C19 (0.72) | CYP2C19PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773826-A4 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1773826-A2 | C-MET MODULATORS AND METHOD OF USE | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014325-A2 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |