Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | PIM1 | P11309 | 2/20 | 0.67 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413785 | 1.00 | MEN1 (0.73) | MEN1KMT2APIM1JAK3ALK | |
| SCHEMBL29638292 | 0.87 | KDR (0.72) | MEN1KMT2AJAK3METAP1KDR | |
| SCHEMBL14674419 | 0.87 | KDR (0.72) | MEN1KMT2AJAK3METAP1KDR | |
| SCHEMBL14674418 | 0.87 | KDR (0.72) | MEN1KMT2AJAK3METAP1KDR | |
| SCHEMBL4411386 | 0.86 | FLT3 (0.56) | MEN1KMT2APIM1JAK3ALK | |
| SCHEMBL4411383 | 0.86 | FLT3 (0.56) | MEN1KMT2APIM1JAK3ALK | |
| SCHEMBL3755027 | 0.85 | FLT3 (0.71) | MEN1KMT2AJAK3ALKKDR | |
| SCHEMBL3755030 | 0.85 | FLT3 (0.71) | MEN1KMT2AJAK3ALKKDR | |
| SCHEMBL13080901 | 0.85 | FLT3 (0.71) | MEN1KMT2AJAK3ALKKDR | |
| SCHEMBL5366302 | 0.84 | MEN1 (0.73) | MEN1KMT2APIM1JAK3METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863315-B2 | 2-indolinone derivatives as selective histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (JP) | 2011-01-04 | — | — | US | disclosed |
| US-20090182029-A1 | 2-INDOLINONE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182029-A1 | 2-INDOLINONE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | MEN1 4334/4885KMT2A 86/4885PIM1 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.