Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | NEK2 | P51955 | 2/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | GRK4 | P32298 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400487 | 0.87 | PLK1 (0.66) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4397738 | 0.85 | PLK1 (0.58) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4397971 | 0.85 | PLK1 (0.57) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL3687448 | 0.82 | PLK1 (0.45) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL14029720 | 0.82 | PLK1 (0.55) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL2973858 | 0.81 | PLK1 (0.68) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL2989088 | 0.81 | PLK1 (0.68) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4397740 | 0.81 | PLK1 (0.55) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4413716 | 0.81 | PLK1 (0.65) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4407330 | 0.80 | PLK1 (0.62) | PLK1PLK3PIK3CDPDGFRBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |