Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038071 | 0.89 | MAP2K1 (0.45) | MAP2K1MAP2K2ABCB11NQO2ACLY | |
| SCHEMBL6016781 | 0.89 | MAP2K1 (0.43) | MAP2K1MAP2K2ABCB11NQO2IDO1 | |
| SCHEMBL1040015 | 0.88 | MAP2K1 (0.46) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL27168260 | 0.87 | MAP2K1 (0.44) | MAP2K1MAP2K2ABCB11NQO2IDO1 | |
| SCHEMBL30434058 | 0.82 | MAP2K1 (0.67) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL29073449 | 0.82 | MAP2K1 (0.67) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL19668525 | 0.82 | MAP2K1 (0.53) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL19668524 | 0.81 | MAP2K1 (0.50) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL6016670 | 0.80 | MAP2K1 (0.48) | MAP2K1MAP2K2ACLYALDH1A1LMNA | |
| SCHEMBL18272624 | 0.80 | MAP2K1 (0.49) | MAP2K1MAP2K2ABCB11NQO2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212832-A1 | PROCESS OF PREPARATION OF BENZIMIDAZOLE COMPOUNDS | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2020-10-22 | — | — | WO | disclosed |
| EP-1482932-B1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2009-11-25 | — | — | EP | disclosed |
| EP-1482932-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-1482932-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |