Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 13/20 | 0.82 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.82 |
| ▸ | KDR | P35968 | 12/20 | 0.82 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.73 |
| ▸ | AKT2 | P31751 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414267 | 1.00 | PDGFRB (0.82) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4409952 | 0.90 | PDGFRB (1.00) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4409949 | 0.90 | PDGFRB (1.00) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4410849 | 0.87 | PDGFRB (0.85) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4410851 | 0.87 | PDGFRB (0.85) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4407137 | 0.86 | PDGFRB (0.81) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4407140 | 0.86 | PDGFRB (0.81) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4408912 | 0.85 | PDGFRB (0.77) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4408910 | 0.85 | PDGFRB (0.77) | PDGFRBFGFR1KDRZAP70AKT2 | |
| SCHEMBL4414657 | 0.85 | PDGFRB (0.80) | PDGFRBFGFR1KDRZAP70AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105151-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. | 2003-06-05 | — | — | US | claimed |
| EP-1082305-A4 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN INC (US) | 2001-09-26 | — | — | EP | claimed |
| EP-1082305-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999061422-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 1999-12-02 | — | — | WO | claimed |
| EP-2020408-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | Sugen, Inc. (US) | 2009-02-04 | — | — | EP | disclosed |
| US-7119090-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-6878733-B1 | Formulations for pharmaceutical agents ionizable as free acids or free bases | SUGEN, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20030105151-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. | 2003-06-05 | — | — | US | disclosed |
| US-6395734-B1 | ANTICANCER AGENTS | SUGEN, INC. | 2002-05-28 | — | — | US | disclosed |
| EP-1082305-A4 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN INC (US) | 2001-09-26 | — | — | EP | disclosed |
| EP-1082305-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061422-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105151-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | DMPK, PDPK1, PLK2 | PDGFRB 1086/4885FGFR1 930/4885KDR 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.