SCHEMBL441507

SCHEMBL441507

Cc1ccc(F)cc1CC(C)Nc1cc[nH]c(=O)c1-c1nc2c(C)c3c(cc2[nH]1)C(=O)N(C1CCN(C)CC1)C3

nearest known ligand 0.79

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 11/20 0.79
ACVRL1 P37023 11/20 0.79
RET P07949 5/20 0.79
ROS1 P08922 5/20 0.79
NTRK3 Q16288 2/20 0.59
NTRK2 Q16620 2/20 0.59
MET P08581 2/20 0.51
IGF1R P08069 9/20 0.40
CYP3A4 P08684 6/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL441505 0.91 NTRK1 (0.78) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL439623 0.89 NTRK1 (0.78) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL441107 0.88 NTRK1 (1.00) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL13692430 0.85 NTRK1 (0.58) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL439789 0.85 NTRK1 (0.66) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL439638 0.81 NTRK1 (0.81) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL14718945 0.80 NTRK1 (0.57) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL13692317 0.80 NTRK1 (0.57) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL438543 0.79 NTRK1 (1.00) NTRK1ACVRL1RETROS1NTRK3
SCHEMBL438567 0.79 NTRK1 (0.69) NTRK1ACVRL1RETROS1NTRK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2489 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024150128-A1 HYBRID ACRYLIC & POLYURETHANE COATING COMPOSITION CONSORCIO COMEX, S.A. DE C.V. (MX) 2024-07-18 WO claimed
WO-2024147839-A1 ELECTRODEPOSITED COATINGS HAVING MULTIPLE RESIN DOMAINS PPG INDUSTRIES OHIO, INC. (US) 2024-07-11 WO claimed
US-12030778-B2 Method for producing semiconducting single-walled carbon nanotube dispersion KAO CORPORATION (JP) 2024-07-09 US claimed
WO-2024145469-A1 WATER SOLUBLE AMPHOTERIC EMULSION TERPOLYMERS, METHODS OF MAKING, AND METHODS OF USE AS RETENTION AND DEWATERING AIDS KEMIRA OYJ (FI) 2024-07-04 WO claimed
WO-2024143285-A1 COPOLYMER RUBBER, RUBBER COMPOSITION, AND CROSSLINKED RUBBER 日本ゼオン株式会社 2024-07-04 WO claimed
WO-2024143976-A1 ELECTRODE COMPOSITION FOR LITHIUM SECONDARY BATTERY, ELECTRODE SLURRY, ELECTRODE, AND LITHIUM SECONDARY BATTERY 주식회사 엘지에너지솔루션 2024-07-04 WO claimed
US-20240218233-A1 AQUEOUS GELLABLE COMPOSITION AND PIPELINE PIGS OBTAINED THEREFROM HALLIBURTON ENERGY SERVICES, INC. (US) 2024-07-04 US claimed
WO-2024145372-A1 TREATMENT OF TAILINGS USING SYNERGISTIC COMBINATION OF FLOCCULANT, COAGULANT, AND 'PROCESS ADDITIVE' KEMIRA OYJ (FI) 2024-07-04 WO claimed
EP-3728512-B1 AQUEOUS FORMULATIONS OF SURFACTANTS AND ASSOCIATIVE POLYMERS FOR THE ASSISTED RECOVERY OF PETROLEUM ENERGY SOLUTIONS US LLC (US) 2024-07-03 EP claimed
WO-2024137036-A1 AQUEOUS GELLABLE COMPOSITION AND PIPELINE PIGS OBTAINED THEREFROM HALLIBURTON ENERGY SERVICES, INC. (US) 2024-06-27 WO claimed
US-4954538-A Papermaking; wet and dry strength AMERICAN CYANAMID COMPANY (US) 1990-09-04 US claimed
EP-0372546-A2 Film-forming resin and hair dressing composition containing the same KAO CORPORATION (JP) 1990-06-13 EP claimed
US-4931525-A Optical active (meth)acrylamides and polymers thereof for racemate resolution BAYER AKTIENGESELLSCHAFT (DE) 1990-06-05 US claimed
US-4920188-A (Meth)acrylate monomer; dental bonding agent MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1990-04-24 US claimed
EP-0217809-B1 POLYMERIC DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-12-13 EP claimed
EP-0323521-A1 CURABLE COMPOSITION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-07-12 EP claimed
EP-0304143-A1 Water-absorptive resin for microbial carrier KYORITSU YUKI CO. LTD. (JP) 1989-02-22 EP claimed
EP-0217809-A1 POLYMERIC DYES. MINNESOTA MINING & MFG (US) 1987-04-15 EP claimed
US-4619990-A Polymeric dyes with pendent chromophore groups capable of undergoing thermoplastic deformation MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1986-10-28 US claimed
WO-1986005505-A1 POLYMERIC DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1986-09-25 WO claimed