Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 20/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.83 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.83 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.83 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.83 |
| ▸ | MLNR | O43193 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | PGR | P06401 | 1/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.83 |
| ▸ | HTR1A | P08908 | 1/20 | 0.83 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7176977 | 1.00 | CYP3A4 (0.83) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7178542 | 0.96 | CYP3A4 (0.83) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7091129 | 0.95 | CYP3A4 (0.84) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7181538 | 0.95 | CYP3A4 (0.81) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7180588 | 0.94 | CYP3A4 (0.84) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7183736 | 0.94 | CYP3A4 (0.84) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7176900 | 0.94 | CYP3A4 (0.84) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7181186 | 0.94 | CYP3A4 (0.83) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL7179514 | 0.92 | CYP3A4 (0.81) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 | |
| SCHEMBL23692882 | 0.92 | CYP3A4 (0.86) | CYP3A4CYP2D6CYP2C19CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428060-B2 | PI-kinase inhibitors with anti-infective activity | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-10-01 | — | — | US | disclosed |
| US-20180170924-A1 | PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2018-06-21 | — | — | US | disclosed |
| WO-2009148541-A1 | PIP-2 INHIBITION-BASED ANTIVIRAL AND ANTI-HYPERLIPIDEMIC THERAPIES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170924-A1 | PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY | PIP4K2A, PIP5K1A, PIP4K2C | CYP3A4 2448/4885CYP2D6 3606/4885CYP2C19 4754/4885 |
| US-10428060-B2 | PI-kinase inhibitors with anti-infective activity | PIP4K2A, PIP5K1A, PIP4K2C | CYP3A4 2448/4885CYP2D6 3606/4885CYP2C19 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.