⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762508 | 0.86 | — | — | |
| SCHEMBL7522014 | 0.85 | CA1 (0.35) | — | |
| SCHEMBL11512048 | 0.83 | KMT2A (0.38) | — | |
| SCHEMBL11532054 | 0.83 | KMT2A (0.38) | — | |
| SCHEMBL12676984 | 0.82 | — | — | |
| SCHEMBL9514913 | 0.77 | — | — | |
| SCHEMBL15088521 | 0.77 | — | — | |
| SCHEMBL16359177 | 0.77 | — | — | |
| SCHEMBL8224538 | 0.77 | — | — | |
| SCHEMBL9621721 | 0.76 | ATM (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12016358-B2 | Composition comprising taste modulation compounds, their use and foodstuff comprising them | V. MANE FILS (FR) | 2024-06-25 | — | — | US | claimed |
| US-11632973-B2 | Composition comprising taste modulation compounds, their use and foodstuff comprising them | V. MANE FILS (FR) | 2023-04-25 | — | — | US | claimed |
| US-20220023381-A1 | VDAC INHIBITORS FOR TREATING AUTOIMMUNE DISEASES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | 2022-01-27 | — | — | US | claimed |
| US-20220023382-A1 | VDAC INHIBITORS FOR TREATING INFLAMMATORY BOWEL DISEASES | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2022-01-27 | — | — | US | claimed |
| EP-3886850-A1 | VDAC INHIBITORS FOR TREATING INFLAMMATORY BOWEL DISEASES | National Institute for Biotechnology in the Negev Ltd. (IL) | 2021-10-06 | — | — | EP | claimed |
| EP-3886849-A1 | VDAC INHIBITORS FOR TREATING AUTOIMMUNE DISEASES | The National Institute for Biotechnology in the Negev, Ltd. (IL) | 2021-10-06 | — | — | EP | claimed |
| EP-3331381-B1 | COMPOSITION COMPRISING TASTE MODULATION COMPOUNDS THEIR USE AND FOODSTUFF COMPRISING THEM | V MANE FILS (FR) | 2021-10-06 | — | — | EP | claimed |
| CN-113365627-A | VDAC inhibitors for the treatment of inflammatory bowel disease | 国家生物技术研究所公司 | 2021-09-07 | — | — | CN | claimed |
| CN-113347973-A | VDAC inhibitors for the treatment of autoimmune diseases | 国家生物技术研究所公司 | 2021-09-03 | — | — | CN | claimed |
| US-20210130291-A1 | METHODS FOR TREATING DIABETES USING VDAC1 INHIBITORS | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2021-05-06 | — | — | US | claimed |
| EP-3331380-A1 | COMPOSITION COMPRISING TASTE MODULATION COMPOUNDS, THEIR USE AND FOODSTUFF COMPRISING THEM | V. Mane Fils (FR) | 2018-06-13 | — | — | EP | claimed |
| US-20180118700-A1 | NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2018-05-03 | — | — | US | claimed |
| US-20180078548-A1 | Methods for Treating Central Nervous System Disorders Using VDAC Inhibitors | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2018-03-22 | — | — | US | claimed |
| WO-2017046794-A1 | NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2017-03-23 | — | — | WO | claimed |
| WO-2017025811-A1 | COMPOSITION COMPRISING TASTE MODULATION COMPOUNDS, THEIR USE AND FOODSTUFF COMPRISING THEM | V. MANE FILS (FR) | 2017-02-16 | — | — | WO | claimed |
| WO-2017025804-A1 | COMPOSITION COMPRISING TASTE MODULATION COMPOUNDS, THEIR USE AND FOODSTUFF COMPRISING THEM | V. MANE FILS (FR) | 2017-02-16 | — | — | WO | claimed |
| WO-2017025810-A2 | COMPOSITION COMPRISING TASTE MODULATION COMPOUNDS, THEIR USE AND FOODSTUFF COMPRISING THEM | V. MANE FILS (FR) | 2017-02-16 | — | — | WO | claimed |
| EP-1613481-B1 | ORGANIC SILVER COMPOUND AND IT'S PREPARATION METHOD, ORGANIC SILVER INK AND IT'S DIRECT WIRING METHOD | HAEUN CHEMTEC CO LTD (KR) | 2013-09-04 | — | — | EP | claimed |
| US-20100163070-A1 | METHOD FOR STRAIGHTENING KERATINOUS FIBRES USING HEATING MEANS AND AN AMIDE | L'OREAL S.A. (FR) | 2010-07-01 | — | — | US | claimed |
| EP-0809103-A2 | Stable denaturants for use in electrophoretic techniques and methods of using the same | FMC CORPORATION (US) | 1997-11-26 | — | — | EP | claimed |