Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 15/20 | 0.58 |
| ▸ | JAK1 | P23458 | 12/20 | 0.58 |
| ▸ | JAK3 | P52333 | 11/20 | 0.58 |
| ▸ | TYK2 | P29597 | 5/20 | 0.58 |
| ▸ | STAT3 | P40763 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | LTK | P29376 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358623 | 0.93 | CCNE1 (0.59) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2356208 | 0.89 | CCNE1 (0.73) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3308989 | 0.84 | CCNE1 (0.57) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2358356 | 0.83 | JAK2 (0.55) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2357638 | 0.82 | CCNE1 (0.57) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2358412 | 0.82 | JAK2 (0.55) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3314144 | 0.81 | CCNE1 (0.58) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2357693 | 0.81 | CCNE1 (0.72) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2356388 | 0.81 | JAK2 (0.58) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3310841 | 0.80 | CCNE1 (0.59) | CCNE1CDK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309718-B2 | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors | INCYTE CORPORATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20090318405-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318405-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | JAK1, JAK2, JAK3 | CCNE1 1514/4885CDK2 135/4885JAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.