Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.65 |
| ▸ | SCARB1 | Q8WTV0 | 9/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418756 | 0.91 | MAPK14 (0.67) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL4416207 | 0.90 | MAPK14 (0.63) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL1600447 | 0.87 | MAPK14 (0.73) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL4952957 | 0.85 | MAPK14 (0.83) | MAPK14SCARB1 | |
| SCHEMBL1599403 | 0.85 | MAPK14 (0.67) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL1600541 | 0.84 | SCARB1 (0.60) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL1600035 | 0.83 | SCARB1 (0.74) | MAPK14SCARB1 | |
| SCHEMBL1599599 | 0.83 | ABL1 (0.81) | MAPK14SCARB1ABL1EGFRRAF1 | |
| SCHEMBL4949130 | 0.82 | MAPK14 (0.71) | MAPK14SCARB1 | |
| SCHEMBL4413512 | 0.82 | SCARB1 (0.68) | MAPK14SCARB1ABL1EGFRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007058990-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2006091862-A2 | CYTOKINE INHIBITORS AND THEIR USE IN THERAPY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |