Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.51 |
| ▸ | RAF1 | P04049 | 6/20 | 0.51 |
| ▸ | KRAS | P01116 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | ARAF | P10398 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5057531 | 0.97 | RAF1 (0.49) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5062792 | 0.92 | KIT (0.49) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5061772 | 0.91 | RAF1 (0.63) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4566603 | 0.89 | BRAF (0.52) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4417370 | 0.87 | BRAF (0.60) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5065212 | 0.84 | BRAF (0.58) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5062767 | 0.83 | BRAF (0.47) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5057532 | 0.83 | BRAF (0.37) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL27758130 | 0.83 | KIT (0.59) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5057469 | 0.83 | RAF1 (0.56) | BRAFRAF1KRASKDRMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553232-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | claimed |
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | BRAF, PRKDC, RAF1 | BRAF 1/4885RAF1 3/4885KRAS 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.