Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432291 | 0.92 | KCNH2 (0.61) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4419254 | 0.90 | HDAC1 (0.57) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4427717 | 0.87 | KCNH2 (0.61) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2207174 | 0.85 | KCNH2 (0.60) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2211783 | 0.84 | KCNH2 (0.67) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2207045 | 0.84 | KCNH2 (0.67) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2209863 | 0.83 | HDAC1 (0.63) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2208198 | 0.82 | KCNH2 (0.60) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2210442 | 0.81 | HDAC1 (0.62) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2211922 | 0.81 | KCNH2 (0.66) | KCNH2HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009544611-A | — | — | 2009-12-17 | — | — | JP | claimed |
| EP-2049124-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | claimed |
| WO-2008010985-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | claimed |