Vindesine

Vindesine

SCHEMBL4420

CC[C@]1(O)C[C@H]2C[N@](CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLNR O43193 1/20 1.00
PTGS2 P35354 1/20 1.00
KCNH2 Q12809 1/20 1.00
GHSR Q92847 1/20 1.00
MEN1 O00255 5/20 0.87
KMT2A Q03164 5/20 0.87
CYP3A4 P08684 4/20 0.87
RECQL P46063 4/20 0.87
TP53 P04637 3/20 0.87
ALOX15 P16050 3/20 0.87
CREBBP Q92793 1/20 0.87
TUBB4A P04350 13/20 0.85
TUBB P07437 13/20 0.85
TUBA3C P0DPH7 13/20 0.85
TUBA1B P68363 13/20 0.85
TUBA4A P68366 13/20 0.85
TUBB4B P68371 13/20 0.85
TUBB3 Q13509 13/20 0.85
TUBB2A Q13885 13/20 0.85
TUBB8 Q3ZCM7 13/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vindesine SCHEMBL13287292 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL6061457 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL14317791 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL13524311 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL13529131 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL15866615 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL15187454 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL21229943 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL20622397 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1
Vindesine SCHEMBL13211594 1.00 MLNR (1.00) MLNRPTGS2KCNH2GHSRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 107083 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144890-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR CONJUGATED TO AN ANTIBODY MyricX Pharma Limited (GB) 2026-05-28 US claimed
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
EP-4743490-A1 HUMANIZED ANTI-CD7 ANTIBODY Christian-Albrechts-Universität zu Kiel (DE) 2026-05-20 EP claimed
US-12630593-B2 Method of killing leukemia cells by administration of recombinant'Y3 proteins UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-19 US claimed
WO-2025136820-A9 POLY-ANTIGEN CYTOKINE-RECEPTOR COMPLEXES (PACCS), COMPOSITIONS, AND METHODS OF USE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2026-05-15 WO claimed
WO-2026099502-A1 NOVEL DRUG CONJUGATES FOR TESTING CELLULAR DRUG UPTAKE Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2026-05-15 WO claimed
WO-2026101236-A1 PEPTIDES SPECIFICALLY BINDING TO CCR8, AND USE THEREOF 경희대학교 산학협력단 2026-05-15 WO claimed
EP-4739310-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-05-13 EP claimed
US-4388305-A LESS TOXIC THAN VINCRISTINE OR VINDESINE OMNICHEM S.A. (BE) 1983-06-14 US claimed
EP-0007206-B1 PHENETHANOLAMINES, THEIR FORMULATIONS, PREPARATION AND USE ELI LILLY AND COMPANY (US) 1983-02-23 EP claimed
EP-0009996-B1 PREPARATION OF VINDESINE MONOSULFATE ELI LILLY AND COMPANY (US) 1983-02-23 EP claimed
WO-1983000150-A1 GLYCOSAMINOGLYCAN DRUG COMPLEXES WALTON, ALAN, G. 1983-01-20 WO claimed
US-4259242-A FREE FROM HEMISULFATE AND DISULFATE ELI LILLY AND COMPANY (US) 1981-03-31 US claimed
EP-0014053-A1 Synthesis of vindesine; vincaleukoblastine compounds ELI LILLY AND COMPANY (US) 1980-08-06 EP claimed
US-4210584-A Vindesine synthesis ELI LILLY AND COMPANY (US) 1980-07-01 US claimed
US-4208414-A Vinblastine in rheumatoid arthritis ELI LILLY AND COMPANY (US) 1980-06-17 US claimed
EP-0009996-A1 Preparation of vindesine monosulfate ELI LILLY AND COMPANY (US) 1980-04-16 EP claimed
EP-0007206-A1 Phenethanolamines, their formulations, preparation and use ELI LILLY AND COMPANY (US) 1980-01-23 EP claimed