⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18114026 | 0.84 | — | — | |
| SCHEMBL15134536 | 0.77 | TSHR (0.33) | — | |
| SCHEMBL28759412 | 0.75 | — | — | |
| SCHEMBL11191983 | 0.73 | — | — | |
| SCHEMBL319872 | 0.73 | — | — | |
| SCHEMBL29282672 | 0.73 | TSHR (0.42) | — | |
| SCHEMBL10842842 | 0.71 | — | — | |
| SCHEMBL1446771 | 0.71 | — | — | |
| SCHEMBL30880451 | 0.71 | — | — | |
| SCHEMBL555929 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 512 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025327-A1 | CONJUGATES OF TUBULYSIN DERIVATIVES AND CELL BINDING MOLECULES AND METHODS OF MAKING | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-01-26 | — | — | US | claimed |
| EP-3991752-A1 | CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR | Hangzhou Dac Biotech Co., Ltd (CN) | 2022-05-04 | — | — | EP | claimed |
| CN-114040778-A | Cell binding molecule-Tubulysin derivative conjugate and preparation method thereof | 杭州多禧生物科技有限公司 | 2022-02-11 | — | — | CN | claimed |
| WO-2021000067-A1 | CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR | 杭州多禧生物科技有限公司 | 2021-01-07 | — | — | WO | claimed |
| CN-117024411-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | disclosed |
| EP-4211119-B1 | 2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | disclosed |
| CN-121850950-A | Preparation method of 2-cyano pyrimidine and 2-methylaminopyrimidine hydrochloride | 南京艾德凯腾生物医药有限责任公司 | 2026-04-14 | — | — | CN | disclosed |
| US-20260091081-A1 | A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-04-02 | — | — | US | disclosed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | disclosed |
| US-12570640-B2 | 2-aminoquinazolines as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof | MERCK SHARP & DOHME LLC (US) | 2026-03-10 | — | — | US | disclosed |
| EP-3826722-B1 | ISOQUINOLINE COMPOUNDS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2026-02-18 | — | — | EP | disclosed |
| US-4496388-A | FUNGICIDES; PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-01-29 | — | — | US | disclosed |
| EP-0078594-A1 | Triazole derivatives, processes for preparing them, compositions containing them and processes for combating fungi and regulating plant growth | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-05-11 | — | — | EP | disclosed |
| US-4107217-A | INTERMEDIATED 3-ALKENALS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4088696-A | MULTISTAGE FROM AN ACETYLENIC KETONE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-05-09 | — | — | US | disclosed |
| US-4045497-A | Processes for producing alkenals and intermediates therefor | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-08-30 | — | — | US | disclosed |
| US-4024190-A | ORGANO-LEPTIC | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-05-17 | — | — | US | disclosed |
| US-3988487-A | Foodstuff flavoring compositions comprising alkylidene alkenals and processes for preparing same as well as flavoring compositions for use in such foodstuff | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1976-10-26 | — | — | US | disclosed |
| US-3970701-A | 2-ETHYLIDENE-3-HEXENAL, ORGANOLEPTIC | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1976-07-20 | — | — | US | disclosed |