⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684202 | 0.70 | — | — | |
| SCHEMBL6526251 | 0.70 | — | — | |
| SCHEMBL309070 | 0.70 | — | — | |
| SCHEMBL312460 | 0.70 | — | — | |
| SCHEMBL7443218 | 0.70 | — | — | |
| SCHEMBL8616381 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL1938631 | 0.68 | — | — | |
| Bromide SCHEMBL1938526 | 0.68 | — | — | |
| SCHEMBL24823866 | 0.67 | — | — | |
| SCHEMBL5527918 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | claimed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | claimed |
| US-20050020832-A1 | Pyridone, pyridazone and triazone derivatives as lp-pla2 inhibitors | SMITHKLINE BEECHAM PLC (GB) | 2005-01-27 | — | — | US | claimed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | claimed |
| US-20040167142-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM P.L.C. | 2004-08-26 | — | — | US | claimed |
| EP-1441731-A1 | PYRIDONE, PYRIDAZONE AND TRIAZONE DERIVATIVES AS LP-PLA2 INHIBITORS | SmithKline Beecham P.L.C. (GB) | 2004-08-04 | — | — | EP | claimed |
| JP-2003524628-A | — | — | 2003-08-19 | — | — | JP | claimed |
| WO-2003041712-A1 | PYRIDONE, PYRIDAZONE AND TRIAZONE DERIVATIVES AS LP-PLA2 INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-05-22 | — | — | WO | claimed |
| WO-2003015786-A1 | 2, 5-SUBSTITUTED 1-(AMINOCARBONYLALKYL) -PYRIMIDIN-4-ONE DERIVATIVES WITH LP-PLA2 INHINITORY ACTIVITY FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-02-27 | — | — | WO | claimed |
| JP-2002543190-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1175409-A1 | PYRIMIDINONES DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | claimed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | claimed |
| WO-2000068208-A1 | PYRIMIDINONES DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-16 | — | — | WO | claimed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | claimed |
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | disclosed |