Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.45 |
| ▸ | USP19 | O94966 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422570 | 1.00 | GSK3B (0.45) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL5554351 | 0.94 | GSK3B (0.46) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL5554356 | 0.94 | GSK3B (0.46) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL4421910 | 0.91 | GSK3B (0.42) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL4421905 | 0.91 | GSK3B (0.42) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL4416870 | 0.90 | KDM4E (0.43) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL4416876 | 0.90 | KDM4E (0.43) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL3365321 | 0.90 | GSK3B (0.50) | GSK3BPIK3R1PIK3CACYP1A2CYP2D6 | |
| SCHEMBL4430878 | 0.89 | GSK3B (0.41) | GSK3BUSP19ALDH1A1TSHRPIK3R1 | |
| SCHEMBL4430874 | 0.89 | GSK3B (0.41) | GSK3BUSP19ALDH1A1TSHRPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547705-B2 | Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives | SANOFI-AVENTIS (FR) | 2009-06-16 | — | — | US | claimed |
| EP-1557417-B1 | Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives | SANOFI AVENTIS (FR) | 2007-03-07 | — | — | EP | claimed |