Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159504 | 0.83 | PTGDR2 (0.65) | PTGIRPTGDR2PTGDR | |
| SCHEMBL16493870 | 0.68 | PTGDR2 (0.48) | PTGIRPTGDR2PTGDRCYP19A1ALDH1A1 | |
| SCHEMBL3169598 | 0.67 | ESR1 (0.48) | CYP19A1OPRM1OPRD1OPRK1 | |
| SCHEMBL3176694 | 0.66 | PTGDR2 (0.51) | PTGIRPTGDR2PTGDRCYP19A1ALDH1A1 | |
| SCHEMBL7772431 | 0.66 | PTGIR (0.73) | PTGIRPTGDRCYP19A1 | |
| SCHEMBL12198738 | 0.64 | PTGIR (0.60) | PTGIRPTGDR2PTGDR | |
| SCHEMBL2510624 | 0.64 | PTGIR (0.60) | PTGIRPTGDR2PTGDR | |
| SCHEMBL7777390 | 0.63 | PTGIR (0.47) | PTGIRPTGDR2PTGDR | |
| SCHEMBL3178973 | 0.63 | PTGDR2 (0.76) | PTGIRPTGDR2PTGDRSMN1; SMN2PDE4A | |
| SCHEMBL3174326 | 0.62 | PTGDR2 (0.56) | PTGIRPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |