Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | RECQL | P46063 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | BLM | P54132 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | APEX1 | P27695 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10621290 | 0.82 | HSD17B10 (0.43) | PTGS2CYP3A4PTGS1TSHRHIF1A | |
| SCHEMBL7262480 | 0.78 | TSHR (0.50) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL891506 | 0.78 | TSHR (0.50) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL7964647 | 0.77 | TSHR (0.61) | BLMKMT2AMEN1CYP3A4TSHR | |
| SCHEMBL8895695 | 0.77 | TDP1 (0.50) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL7192536 | 0.77 | TDP1 (0.50) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL6875459 | 0.75 | ESR1 (0.44) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL29102057 | 0.74 | TDP1 (0.68) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL9347001 | 0.74 | TDP1 (0.51) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL10786647 | 0.72 | BLM (0.61) | TDP1KDM4ERECQLMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511500-A4 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | EPIGENESIS PHARMACEUTICALS LLC (US) | 2009-04-29 | — | — | EP | claimed |
| JP-2006504666-A | — | — | 2006-02-09 | — | — | JP | claimed |
| EP-1511500-A2 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | Epigenesis Pharmaceuticals, Inc. (US) | 2005-03-09 | — | — | EP | claimed |
| WO-2004014293-A2 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | EPIGENESIS PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | claimed |
| US-20030216329-A1 | Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s) | EPEGENESIS PHARMACEUTICALS, INC. | 2003-11-20 | — | — | US | claimed |
| US-6284750-B1 | DRUG, COSMETICS STEROID | ESTEE LAUDER INC. | 2001-09-04 | — | — | US | claimed |
| EP-0876391-B1 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER INC (US) | 2000-08-16 | — | — | EP | claimed |
| US-6025347-A | Steroid esters useful against skin disorders | ESTEE LAUDER INC. (US) | 2000-02-15 | — | — | US | claimed |
| US-5948418-A | MERCAPTANS | ESTEE LAUDER, INC. (US) | 1999-09-07 | — | — | US | claimed |
| EP-0876391-A4 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER INC (US) | 1998-12-30 | — | — | EP | claimed |
| EP-0876391-A1 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER INC. (US) | 1998-11-11 | — | — | EP | claimed |
| US-5683705-A | Sulfur-based amides and bis-amides useful against skin disorders | ESTEE LAUDER, INC. (US) | 1997-11-04 | — | — | US | claimed |
| WO-1997010255-A1 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER, INC. (US) | 1997-03-20 | — | — | WO | claimed |
| US-6284750-B1 | DRUG, COSMETICS STEROID | ESTEE LAUDER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0876391-B1 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER INC (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6025347-A | Steroid esters useful against skin disorders | ESTEE LAUDER INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5948418-A | MERCAPTANS | ESTEE LAUDER, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| US-5736537-A | Dehydroep:androsterone sailcylate useful against skin atrophy | ESTEE LAUDER, INC. (US) | 1998-04-07 | — | — | US | disclosed |
| US-5683705-A | Sulfur-based amides and bis-amides useful against skin disorders | ESTEE LAUDER, INC. (US) | 1997-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216329-A1 | Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s) | KIT, NR5A1, CHRM5 | TDP1 3506/4885KDM4E 1130/4885RECQL 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.