Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5065364 | 0.89 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5065431 | 0.86 | BRAF (0.46) | MAPK14MAPK13MAPK12MAPK11SRC | |
| SCHEMBL4563409 | 0.85 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5061595 | 0.85 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL4429207 | 0.85 | ABL1 (0.55) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5062510 | 0.83 | KCNJ6 (0.49) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5065442 | 0.83 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL4416685 | 0.83 | BRAF (0.43) | MAPK14MAPK13MAPK12MAPK11SRC | |
| SCHEMBL5066988 | 0.81 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL5067085 | 0.81 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |