Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249076 | 0.69 | RAF1 (0.67) | MAPK14RAF1 | |
| SCHEMBL3217612 | 0.67 | MAPK14 (0.52) | MAPK14RAF1ALDH1A1GAA | |
| SCHEMBL10308265 | 0.63 | MAPK14 (0.50) | MAPK14RAF1ALDH1A1GAA | |
| SCHEMBL3226707 | 0.60 | MAPK14 (1.00) | MAPK14RAF1ALDH1A1 | |
| SCHEMBL4429666 | 0.59 | RAF1 (0.52) | MAPK14RAF1 | |
| SCHEMBL4426603 | 0.56 | MAPK14 (0.53) | MAPK14RAF1 | |
| SCHEMBL425794 | 0.55 | DAO (0.65) | ALDH1A1GAA | |
| SCHEMBL11456343 | 0.54 | DAO (0.42) | ALDH1A1GAA | |
| SCHEMBL3226636 | 0.54 | MAPK14 (0.40) | MAPK14RAF1ALDH1A1 | |
| SCHEMBL11193741 | 0.52 | KDM4E (0.49) | MAPK14RAF1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4344960-B2 | — | — | 2009-10-14 | — | — | JP | claimed |
| JP-2001526687-A | — | — | 2001-12-18 | — | — | JP | claimed |
| EP-1019040-A4 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER AG (US) | 2000-10-04 | — | — | EP | claimed |
| EP-1019040-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | Bayer Corporation (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1998052558-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER CORPORATION (US) | 1998-11-26 | — | — | WO | claimed |