Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.67 |
| ▸ | SRC | P12931 | 5/20 | 0.67 |
| ▸ | EGFR | P00533 | 4/20 | 0.67 |
| ▸ | ABL1 | P00519 | 4/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | SIK2 | Q9H0K1 | 5/20 | 0.58 |
| ▸ | SIK1 | P57059 | 4/20 | 0.58 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.58 |
| ▸ | STK4 | Q13043 | 1/20 | 0.57 |
| ▸ | STK3 | Q13188 | 1/20 | 0.57 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.57 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.57 |
| ▸ | WEE1 | P30291 | 4/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30078208 | 1.00 | FGFR1 (0.67) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL24885903 | 0.87 | SRC (0.58) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL30078171 | 0.87 | SRC (0.58) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL30078142 | 0.82 | WEE1 (0.76) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL24885870 | 0.82 | WEE1 (0.76) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL30078284 | 0.82 | WEE1 (0.59) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL24885871 | 0.82 | WEE1 (0.59) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL4420167 | 0.82 | FGFR1 (0.51) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL5061792 | 0.81 | ABL1 (0.67) | FGFR1SRCEGFRABL1PDGFRB | |
| SCHEMBL5762058 | 0.80 | FGFR1 (1.00) | FGFR1SRCEGFRABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400577-A1 | MODULATORS OF PROTEIN KINASES | VIBLIOME THERAPEUTICS, LLC | 2024-12-05 | — | — | US | disclosed |
| WO-2023283369-A1 | MODULATORS OF PROTEIN KINASES | VIBLIOME THERAPEUTICS, LLC (US) | 2023-01-12 | — | — | WO | disclosed |
| US-20120289540-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-8188113-B2 | For example, 1-(5-(2-amino-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-2-fluorophenyl)-3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240400577-A1 | MODULATORS OF PROTEIN KINASES | MAP3K20, PRKCE, PRKCH | FGFR1 1581/4885SRC 121/4885EGFR 862/4885 |
| US-20120289540-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | BRAF, PRKDC, RAF1 | FGFR1 577/4885SRC 417/4885EGFR 349/4885 |
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | BRAF, PRKDC, RAF1 | FGFR1 577/4885SRC 417/4885EGFR 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.