Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 4/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 3/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 8/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30711773 | 1.00 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL5792146 | 0.98 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL17601433 | 0.81 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL18646838 | 0.81 | CYP19A1 (0.61) | HSP90AA1HSP90AB1PTK2CYP2A6CYP19A1 | |
| SCHEMBL22068195 | 0.81 | ABL1 (0.68) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL445042 | 0.80 | MEN1 (0.59) | HSP90AA1HSP90AB1ABL1PRKCAPRKCD | |
| Pyrazine SCHEMBL28285881 | 0.79 | KMT2A (0.53) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL20354418 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL13401647 | 0.78 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1PTK2ABL1PRKCA | |
| SCHEMBL10817967 | 0.78 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1PTK2ABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041310-B | Preparation method and application of imatinib derivative | 山东师范大学 | 2020-06-16 | — | — | CN | claimed |
| CN-110041310-A | A kind of preparation method and application of Imatinib derivative | 山东师范大学 | 2019-07-23 | — | — | CN | claimed |
| CN-101654416-A | N-[3-nitro-4-methyl-phenyl]-4-aldehyde group-benzamide and preparation method thereof as well as preparation method of derivatives thereof | CHENGDU HUTCHISON CHINA MEDICI | 2010-02-24 | — | — | CN | claimed |
| US-7507821-B2 | Process for preparing Imatinib | CHEMAGIS LTD. (IL) | 2009-03-24 | — | — | US | claimed |
| US-20060149061-A1 | Novel process for preparing Imatinib | PERRIGO API LTD. (IL) | 2006-07-06 | — | — | US | claimed |
| WO-2025231152-A1 | COMPOUNDS AND METHODS FOR RESTORING BETA-ADRENERGIC RECEPTOR FUNCTION | THE CLEVELAND CLINIC FOUNDATION (US) | 2025-11-06 | — | — | WO | disclosed |
| US-20250188068-A1 | AMIDO CYCLOPROPYL DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-06-12 | — | — | US | disclosed |
| US-20250066341-A1 | CYCLOHEXANE ACID DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-02-27 | — | — | US | disclosed |
| US-11897868-B2 | Heterocyclic inhibitors of PCSK9 | Cardio Therapeutics Pty Ltd (AU) | 2024-02-13 | — | — | US | disclosed |
| CN-117510513-A | Heterocyclic compounds having biological activity | 首药控股(北京)股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2024022244-A1 | HETEROCYCLIC COMPOUND HAVING BIOLOGICAL ACTIVITY | 首药控股(北京)股份有限公司 | 2024-02-01 | — | — | WO | disclosed |
| US-11793821-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | MERCK SHARP & DOHME LLC (US) | 2023-10-24 | — | — | US | disclosed |
| EP-1675584-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2006-07-05 | — | — | EP | disclosed |
| US-7071216-B2 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | CHIRON CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |
| WO-2005032548-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
| EP-1499311-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | Chiron Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2004074287-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-02 | — | — | WO | disclosed |
| US-20040122237-A1 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase | NOVARTIS AG (CH) | 2004-06-24 | — | — | US | disclosed |
| US-20040087626-A1 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | NOVARTIS AG (CH) | 2004-05-06 | — | — | US | disclosed |
| WO-2003082272-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122237-A1 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase | BRAF, RAF1, ARAF | HSP90AA1 1044/4885HSP90AB1 797/4885PTK2 439/4885 |
| US-20040087626-A1 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | BRAF, RAF1, ARAF | HSP90AA1 1349/4885HSP90AB1 1004/4885PTK2 486/4885 |
| US-11793821-B2 | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors | CHRNA7, CHRNA6, CHRNA5 | HSP90AA1 3838/4885HSP90AB1 3529/4885PTK2 953/4885 |
| US-11897868-B2 | Heterocyclic inhibitors of PCSK9 | PCSK9, PCSK6, PCSK7 | HSP90AA1 4555/4885HSP90AB1 4220/4885PTK2 3570/4885 |
| US-20250066341-A1 | CYCLOHEXANE ACID DERIVATIVES AS LPA RECEPTOR INHIBITORS | LPAR1, LPAR2, LPAR3 | HSP90AA1 2896/4885HSP90AB1 3030/4885PTK2 691/4885 |
| US-20250188068-A1 | AMIDO CYCLOPROPYL DERIVATIVES AS LPA RECEPTOR INHIBITORS | LPAR1, LPAR2, LPAR3 | HSP90AA1 3075/4885HSP90AB1 2793/4885PTK2 538/4885 |
| US-20060149061-A1 | Novel process for preparing Imatinib | ABL1, ABL2, PDGFRA | HSP90AA1 2642/4885HSP90AB1 2601/4885PTK2 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.