Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.43 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.43 |
| ▸ | INPP5B | P32019 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11383659 | 0.86 | S1PR1 (0.50) | GLASMN1; SMN2S1PR1S1PR3S1PR2 | |
| SCHEMBL6480565 | 0.84 | INPPL1 (0.44) | SMN1; SMN2S1PR1S1PR3S1PR2INPPL1 | |
| SCHEMBL27778654 | 0.82 | INPPL1 (0.43) | SMN1; SMN2S1PR1S1PR3S1PR2INPPL1 | |
| SCHEMBL29282874 | 0.80 | S1PR1 (0.41) | S1PR1S1PR3S1PR2INPPL1INPP5A | |
| SCHEMBL10978864 | 0.80 | GLA (0.44) | GLASMN1; SMN2S1PR1S1PR3S1PR2 | |
| SCHEMBL21407745 | 0.80 | NPC1 (0.50) | SMN1; SMN2INPPL1INPP5AINPP5B | |
| SCHEMBL13241453 | 0.78 | SMN1; SMN2 (0.56) | GLASMN1; SMN2ATM | |
| SCHEMBL5085353 | 0.77 | S1PR1 (0.41) | S1PR1S1PR3S1PR2INPPL1INPP5A | |
| SCHEMBL7767259 | 0.77 | INPPL1 (0.43) | SMN1; SMN2S1PR1S1PR3S1PR2INPPL1 | |
| SCHEMBL2039626 | 0.75 | GLA (0.48) | GLASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097428-A2 | BUTYRYLCHOLINESTERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Mgp Biotechnologies, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008055249-A2 | BUTYRYLCHOLINESTERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | MGP BIOTECHNOLOGIES, INC. (US) | 2008-05-08 | — | — | WO | disclosed |