Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106257 | 0.96 | HDAC4 (0.57) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL18386011 | 0.89 | HDAC4 (0.50) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| Water SCHEMBL18063169 | 0.84 | HDAC4 (0.49) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL1981762 | 0.82 | HDAC3 (0.44) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL9673769 | 0.82 | HDAC3 (0.44) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL30854423 | 0.79 | HDAC3 (0.52) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL9672991 | 0.79 | NTRK1 (0.41) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL1230255 | 0.78 | HDAC3 (0.41) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL14149267 | 0.78 | HDAC3 (0.42) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL3331522 | 0.77 | MAPT (0.46) | POLBALDH1A1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029127-A1 | NEW LONG-ACTING DRUG COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007135024-A1 | NEW LONG-ACTING DRUG COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |