Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.48 |
| ▸ | RAF1 | P04049 | 8/20 | 0.48 |
| ▸ | KRAS | P01116 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.45 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.45 |
| ▸ | PAK3 | O75914 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | SIK1 | P57059 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5057573 | 0.99 | BRAF (0.48) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5066950 | 0.89 | BRAF (0.46) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4420200 | 0.84 | BRAF (0.49) | BRAFRAF1KRASKDRMAP2K2 | |
| Hydrochloric Acid SCHEMBL4419083 | 0.83 | BRAF (0.48) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5055210 | 0.83 | BRAF (0.48) | BRAFRAF1KRASKDRMAP2K2 | |
| Hydrochloric Acid SCHEMBL5065369 | 0.82 | BRAF (0.47) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4563066 | 0.79 | BRAF (0.56) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4424987 | 0.79 | BRAF (0.56) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL4270638 | 0.79 | KDR (0.53) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5062718 | 0.79 | BRAF (0.58) | BRAFRAF1KRASKDRMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | claimed |