Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210604 | 0.91 | HDAC1 (0.81) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL4421483 | 0.90 | HDAC1 (0.69) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL2208419 | 0.87 | HDAC1 (0.81) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL2207178 | 0.85 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL4421191 | 0.84 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL2206038 | 0.84 | HDAC1 (0.75) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL2206044 | 0.84 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL2206410 | 0.84 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL4311544 | 0.83 | HDAC1 (0.64) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2212087 | 0.83 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049124-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008010985-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |