Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.72 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367326 | 0.94 | USP30 (0.77) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL12715428 | 0.87 | USP30 (0.73) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL124363 | 0.84 | USP30 (1.00) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL16526167 | 0.82 | USP30 (0.67) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL442120 | 0.80 | USP30 (0.58) | USP30DGAT1 | |
| SCHEMBL1367328 | 0.79 | USP30 (0.49) | USP30BACE1BACE2 | |
| SCHEMBL17643639 | 0.78 | USP30 (0.59) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL152977 | 0.78 | USP30 (0.56) | USP30DGAT1 | |
| SCHEMBL31093315 | 0.78 | USP30 (0.61) | USP30BACE1BACE2DGAT1AAK1 | |
| SCHEMBL799138 | 0.74 | USP30 (0.53) | USP30BACE1BACE2DGAT1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300466-B1 | IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-08-06 | — | — | EP | disclosed |
| US-8338604-B2 | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-12-25 | — | — | US | disclosed |
| WO-2009155388-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009155389-A1 | TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-23 | — | — | WO | disclosed |