Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428888 | 0.96 | GRM2 (0.63) | GRM2L3MBTL1MAPK1POLBKMT2A | |
| SCHEMBL3143906 | 0.88 | GRM2 (0.67) | GRM2L3MBTL1MAPK1POLBKMT2A | |
| SCHEMBL3138881 | 0.86 | GRM2 (0.72) | GRM2L3MBTL1MAPK1POLBKMT2A | |
| SCHEMBL1516279 | 0.84 | GRM2 (0.73) | GRM2L3MBTL1MAPK1 | |
| SCHEMBL3134465 | 0.83 | GRM2 (0.69) | GRM2L3MBTL1POLBKMT2AKDM4E | |
| SCHEMBL3134451 | 0.83 | GRM2 (0.69) | GRM2L3MBTL1POLBKMT2AKDM4E | |
| SCHEMBL3138911 | 0.82 | GRM2 (0.71) | GRM2L3MBTL1MAPK1KDM4EMAPT | |
| SCHEMBL1513227 | 0.82 | GRM2 (0.72) | GRM2L3MBTL1MAPK1POLBKMT2A | |
| SCHEMBL3138930 | 0.82 | GRM2 (0.71) | GRM2L3MBTL1MAPK1KDM4EMAPT | |
| SCHEMBL1513224 | 0.82 | GRM2 (0.72) | GRM2L3MBTL1MAPK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | claimed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | claimed |
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |