Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | ATF4 | P18848 | 5/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438509 | 0.89 | HPGD (0.53) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL4033454 | 0.85 | HPGD (0.49) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL14785106 | 0.82 | HPGD (0.46) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL4430412 | 0.81 | HPGD (0.45) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL446351 | 0.81 | HDAC3 (0.58) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL4255648 | 0.78 | HDAC3 (0.55) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL4432409 | 0.78 | KMT2A (0.55) | SMN1; SMN2HPGDTSHRHDAC1HDAC2 | |
| SCHEMBL4438351 | 0.77 | HPGD (0.48) | SMN1; SMN2HPGDTSHRHSD17B10MEN1 | |
| SCHEMBL445062 | 0.75 | HDAC1 (0.64) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 | |
| SCHEMBL14918163 | 0.72 | HDAC4 (0.54) | SMN1; SMN2HPGDTSHRHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099442-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008082856-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |