Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003424 | 0.86 | NPC1 (0.47) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| Hydrochloric Acid SCHEMBL20640295 | 0.85 | NPC1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| Hydrochloric Acid SCHEMBL9937789 | 0.85 | NPC1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| Hydrochloric Acid SCHEMBL6053050 | 0.85 | NPC1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL30525283 | 0.84 | NPC1 (0.53) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL30525272 | 0.84 | NPC1 (0.53) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL4049974 | 0.84 | NPC1 (0.53) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL6053120 | 0.83 | NPC1 (0.51) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| Hydrochloric Acid SCHEMBL6053028 | 0.83 | NPC1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2NOTUM | |
| SCHEMBL2003422 | 0.83 | NPC1 (0.47) | NPC1HPGDRAB9ASMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101563351-B | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2013-06-05 | — | — | CN | disclosed |
| CN-102079746-A | Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2011-06-01 | — | — | CN | disclosed |
| EP-2125822-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-12-02 | — | — | EP | disclosed |
| CN-101563351-A | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-10-21 | — | — | CN | disclosed |
| WO-2008074788-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | disclosed |
| CN-1826343-A | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2006-08-30 | — | — | CN | disclosed |