Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.36 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.36 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.36 |
| ▸ | RPS17 | P08708 | 2/20 | 0.36 |
| ▸ | RPSA | P08865 | 2/20 | 0.36 |
| ▸ | RPS2 | P15880 | 2/20 | 0.36 |
| ▸ | RPL35A | P18077 | 2/20 | 0.36 |
| ▸ | RPL7 | P18124 | 2/20 | 0.36 |
| ▸ | RPL17 | P18621 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335575 | 0.78 | HRH2 (0.41) | HTR2ASMN1; SMN2 | |
| SCHEMBL8169931 | 0.73 | JAK2 (0.41) | HTR2ACYP2D6SMN1; SMN2NPC1 | |
| SCHEMBL3334782 | 0.70 | CYP3A4 (0.44) | CYP2D6SMN1; SMN2NOS2NPC1 | |
| SCHEMBL3334079 | 0.69 | KDM4E (0.58) | HTR2AKDM4ESMN1; SMN2 | |
| SCHEMBL8169539 | 0.69 | JAK2 (0.50) | SLC6A4NOS2 | |
| SCHEMBL3331527 | 0.69 | MEN1 (0.55) | HTR2AKDM4ESMN1; SMN2 | |
| SCHEMBL11448021 | 0.66 | CHRM3 (0.52) | KDM4ECYP2D6SMN1; SMN2KCNH2CHRM2 | |
| SCHEMBL3947609 | 0.66 | HTR2A (0.56) | HTR2AKCNH2SLC6A4 | |
| SCHEMBL3338157 | 0.66 | KDM4E (0.58) | HTR2AKDM4ESMN1; SMN2 | |
| SCHEMBL22878508 | 0.65 | SLC6A2 (0.47) | CYP2D6SMN1; SMN2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134687-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | AstraZeneca AB (SE) | 2009-12-23 | — | — | EP | claimed |
| WO-2008112440-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | WO | claimed |