Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.34 |
| ▸ | TNF | P01375 | 4/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.32 |
| ▸ | CIT | O14578 | 1/20 | 0.32 |
| ▸ | MUSK | O15146 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | STK10 | O94804 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570024 | 0.83 | BRAF (0.38) | ACKR3MAPK14MAPK13TNFMAPK12 | |
| SCHEMBL5063064 | 0.67 | BRAF (0.45) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL13718729 | 0.66 | MAPK14 (0.35) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4416685 | 0.64 | BRAF (0.43) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL5057338 | 0.62 | BRAF (0.52) | MAPK14MAPK13MAPK12MAPK11RIPK2 | |
| SCHEMBL5061639 | 0.61 | BRAF (0.43) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL3884674 | 0.60 | MAPK14 (0.55) | MAPK14MAPK13TNFMAPK12MAPK11 | |
| SCHEMBL2951303 | 0.59 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL3876529 | 0.59 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4425259 | 0.59 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |