Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | USP19 | O94966 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554395 | 0.95 | GSK3B (0.44) | GSK3BALDH1A1TSHRGRM5USP19 | |
| SCHEMBL3366965 | 0.91 | GSK3B (0.47) | GSK3BALDH1A1TSHRGRM5CYP2D6 | |
| SCHEMBL4422560 | 0.91 | GSK3B (0.40) | GSK3BALDH1A1TSHRGRM5USP19 | |
| SCHEMBL4423186 | 0.90 | GSK3B (0.41) | GSK3BALDH1A1USP19CYP1A2USP2 | |
| SCHEMBL4421861 | 0.89 | GSK3B (0.47) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL4424995 | 0.89 | GSK3B (0.39) | GSK3BALDH1A1TSHRUSP19CYP2D6 | |
| SCHEMBL3368275 | 0.89 | GSK3B (0.46) | GSK3BALDH1A1TSHRGRM5USP19 | |
| SCHEMBL3364367 | 0.89 | GSK3B (0.46) | GSK3BALDH1A1TSHRGRM5CYP2D6 | |
| SCHEMBL5560272 | 0.89 | GSK3B (0.44) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL5560279 | 0.89 | GSK3B (0.44) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547705-B2 | Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives | SANOFI-AVENTIS (FR) | 2009-06-16 | — | — | US | claimed |
| EP-1699795-B1 | SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKLYMINE]-PYRIMIDO[1,2A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI AVENTIS (FR) | 2007-04-25 | — | — | EP | claimed |
| EP-1557417-B1 | Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives | SANOFI AVENTIS (FR) | 2007-03-07 | — | — | EP | claimed |
| US-7547705-B2 | Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives | SANOFI-AVENTIS (FR) | 2009-06-16 | — | — | US | disclosed |