Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4152022 | 0.69 | AHR (0.42) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL1162926 | 0.67 | AHR (1.00) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL1764695 | 0.65 | AHR (0.70) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL11534863 | 0.65 | AHR (0.59) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL25369916 | 0.64 | AHR (0.49) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL30528633 | 0.64 | AHR (0.49) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL11708913 | 0.63 | AHR (0.47) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL3284838 | 0.62 | AHR (0.86) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL31430300 | 0.62 | AHR (0.54) | AHRHTR5ANSD2BCHEDAO | |
| SCHEMBL3878574 | 0.61 | MAPT (0.56) | AHRHTR5APNMTMAPTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |