Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | ERN1 | O75460 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41746 | 0.95 | KDR (0.67) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL1401640 | 0.83 | KDR (0.65) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL15966394 | 0.83 | KDR (0.76) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL665691 | 0.83 | KDR (0.73) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL16693713 | 0.83 | KDR (0.76) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL3201243 | 0.82 | KDR (0.73) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL1401711 | 0.82 | KDR (0.75) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL296675 | 0.82 | KDR (0.75) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL1401693 | 0.82 | KDR (0.65) | KDRRETPDGFRBPLK4GAK | |
| SCHEMBL1401672 | 0.82 | KDR (0.65) | KDRRETPDGFRBPLK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132184-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104754-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |