Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604739 | 0.84 | HRH4 (0.41) | HRH4ERN1MCHR1JAK1JAK2 | |
| SCHEMBL603849 | 0.76 | F2 (0.36) | HRH4 | |
| SCHEMBL601656 | 0.73 | HRH4 (0.42) | HRH4MCHR1 | |
| SCHEMBL602516 | 0.73 | HRH4 (0.38) | HRH4MCHR1 | |
| SCHEMBL604984 | 0.71 | HRH4 (0.53) | HRH4ERN1JAK1 | |
| SCHEMBL606695 | 0.70 | HRH4 (0.56) | HRH4 | |
| SCHEMBL4009401 | 0.70 | BCHE (0.44) | — | |
| SCHEMBL602819 | 0.69 | CHEK2 (0.43) | — | |
| SCHEMBL2166688 | 0.67 | HRH4 (0.56) | HRH4JAK1 | |
| SCHEMBL602542 | 0.67 | HRH4 (0.49) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079001-A1 | BICYCLIC HETEROARYL-SUBSTITUTED IMIDAZOLES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | disclosed |