Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906878 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL2457476 | 0.86 | NPSR1 (0.39) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL5526779 | 0.80 | MAPT (0.51) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| Hydrochloric Acid SCHEMBL4435716 | 0.79 | SMN1; SMN2 (0.36) | MAPTALDH1A1NPSR1CYP3A4MEN1 | |
| SCHEMBL14393120 | 0.78 | MAPT (0.50) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| Hydrochloric Acid SCHEMBL5526775 | 0.78 | MAPT (0.50) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL4825839 | 0.77 | MAPT (0.49) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| Hydrochloric Acid SCHEMBL25233263 | 0.77 | MAPT (0.49) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL12870428 | 0.77 | MAPT (0.49) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 | |
| SCHEMBL27831272 | 0.77 | MAPT (0.57) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121624-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008092878-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |