Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64733 | 0.95 | OGA (0.47) | OGAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL64090 | 0.83 | HDAC3 (0.57) | OGAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL23370098 | 0.83 | MAPT (0.54) | OGAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19295845 | 0.82 | OGA (0.52) | OGAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4456976 | 0.82 | PTPN11 (0.48) | HDAC3HDAC1HDAC2HDAC8PTPN11 | |
| SCHEMBL7528163 | 0.82 | KMT2A (0.68) | OGAAOC3KMT2ANPC1RAB9A | |
| SCHEMBL15341329 | 0.81 | MAPT (0.53) | OGAAOC3KMT2ANPC1RAB9A | |
| SCHEMBL3957492 | 0.81 | HDAC6 (0.57) | HDAC3HDAC1HDAC2HDAC8KMT2A | |
| SCHEMBL15341333 | 0.80 | OGA (0.46) | OGAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL64037 | 0.80 | OGA (0.43) | OGAHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |