Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.55 |
| ▸ | PIM1 | P11309 | 7/20 | 0.55 |
| ▸ | GSK3B | P49841 | 7/20 | 0.52 |
| ▸ | PRKCA | P17252 | 4/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436035 | 0.82 | PIM2 (0.79) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11984304 | 0.81 | PIM2 (0.57) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL4432032 | 0.80 | PIM2 (0.60) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11908595 | 0.80 | PIM2 (0.80) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11906844 | 0.79 | PIM2 (0.76) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11906883 | 0.78 | PIM2 (0.57) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL14067717 | 0.77 | PIM2 (0.56) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11907433 | 0.77 | PIM2 (0.55) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11984605 | 0.76 | PIM2 (0.58) | PIM2PIM3PIM1GSK3BPRKCA | |
| SCHEMBL11984735 | 0.76 | PIM2 (0.79) | PIM2PIM3PIM1GSK3BPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |