Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913504 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL15873410 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL13734129 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1710226 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11899431 | 0.92 | MEN1 (0.38) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11898640 | 0.92 | MEN1 (0.38) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL15873409 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11898639 | 0.92 | MEN1 (0.38) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1710224 | 0.92 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11899432 | 0.92 | MEN1 (0.38) | MEN1KMT2AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |