Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 7/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | ESRRB | O95718 | 3/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431311 | 0.88 | ESRRG (0.53) | ESRRGTRPV1ADRB2ADRB1ADRB3 | |
| SCHEMBL4431844 | 0.87 | ESRRG (0.48) | ESRRGTRPV1PRMT5WDR77ADRB2 | |
| SCHEMBL4441800 | 0.82 | ESRRG (0.48) | ESRRGTRPV1ADRB2ADRB1ADRB3 | |
| SCHEMBL4441792 | 0.79 | ESRRG (0.57) | ESRRGADRB2ADRB1ADRA1DADRA1A | |
| SCHEMBL4432919 | 0.78 | ESRRG (0.53) | ESRRGESRRBNPC1POLBRAB9A | |
| SCHEMBL4435971 | 0.77 | ESRRG (0.53) | ESRRGESRRBNPC1POLBRAB9A | |
| SCHEMBL4432676 | 0.77 | ESRRG (0.50) | ESRRGESRRBNPC1POLBRAB9A | |
| SCHEMBL4439018 | 0.76 | ESRRG (0.52) | ESRRGESRRBNPC1POLBRAB9A | |
| SCHEMBL4431299 | 0.76 | ESRRG (0.52) | ESRRGTRPV1ESRRBNPC1RAB9A | |
| SCHEMBL3465734 | 0.73 | ESRRG (0.48) | ESRRGTRPV1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137178-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008125342-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2008-10-23 | — | — | WO | claimed |
| EP-2137178-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125342-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2008-10-23 | — | — | WO | disclosed |