Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434720 | 0.92 | S1PR1 (0.46) | S1PR1GPR119S1PR3 | |
| SCHEMBL4427175 | 0.84 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL4431917 | 0.83 | S1PR1 (0.53) | S1PR1S1PR4CYP2C9S1PR3S1PR5 | |
| SCHEMBL4426387 | 0.83 | S1PR1 (0.47) | S1PR1S1PR4CYP2C9S1PR3S1PR5 | |
| SCHEMBL4422244 | 0.82 | S1PR1 (0.58) | S1PR1S1PR4CYP2C9S1PR3S1PR5 | |
| SCHEMBL4425933 | 0.81 | S1PR1 (0.56) | S1PR1S1PR4S1PR3S1PR5 | |
| SCHEMBL4419503 | 0.81 | S1PR1 (0.57) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4419359 | 0.81 | S1PR1 (0.58) | S1PR1S1PR4S1PR5 | |
| SCHEMBL4565950 | 0.78 | S1PR1 (0.60) | S1PR1S1PR3 | |
| SCHEMBL4566635 | 0.78 | S1PR1 (0.42) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151626-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |