Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.69 |
| ▸ | CSF1R | P07333 | 11/20 | 0.69 |
| ▸ | FLT3 | P36888 | 5/20 | 0.62 |
| ▸ | KIT | P10721 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922906 | 0.88 | KDR (0.78) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729954 | 0.87 | KDR (0.65) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729918 | 0.87 | KDR (0.65) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729110 | 0.87 | KDR (0.65) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729205 | 0.83 | KDR (0.63) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729206 | 0.83 | KDR (0.63) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL739818 | 0.83 | KDR (0.75) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL10151718 | 0.83 | KDR (0.75) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729273 | 0.83 | KDR (0.75) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729275 | 0.83 | KDR (0.75) | KDRCSF1RFLT3KITCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137184-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124323-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-16 | — | — | WO | disclosed |