Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 6/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435467 | 1.00 | TSHR (0.55) | TSHRHPGDAPPATMALOX5 | |
| SCHEMBL585289 | 0.94 | APP (0.59) | APPATMALOX5CYP3A4HCAR2 | |
| SCHEMBL585288 | 0.94 | APP (0.59) | APPATMALOX5CYP3A4HCAR2 | |
| SCHEMBL585889 | 0.83 | APP (0.59) | APPATMALOX5CYP3A4HCAR2 | |
| SCHEMBL585888 | 0.83 | APP (0.59) | APPATMALOX5CYP3A4HCAR2 | |
| SCHEMBL584879 | 0.82 | APP (0.55) | TSHRHPGDAPPATMALOX5 | |
| SCHEMBL584880 | 0.82 | APP (0.55) | TSHRHPGDAPPATMALOX5 | |
| SCHEMBL584661 | 0.81 | APP (0.56) | APPATMALOX5LMNASMN1; SMN2 | |
| SCHEMBL584660 | 0.81 | APP (0.56) | APPATMALOX5LMNASMN1; SMN2 | |
| SCHEMBL1569089 | 0.80 | APP (0.54) | TSHRHPGDAPPALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125823-A1 | 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008078291-A1 | 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-03 | — | — | WO | disclosed |